Schizophrenia Adult Initially 10 or 15 mg once daily. Maintenance: 15 mg daily. Dose range: 10-30 mg daily.
Adolescent 13-17 yr Recommended target dose: 10 mg daily. Initially 2 mg, then titrated to 5 mg after 2 days & additional 2 days to reach the target dose of 10 mg. Subsequently, increase dose to 5 mg increments. Max: 30 mg daily.
Acute treatment of manic & mixed episodes of bipolar I disorder Adult Initially 15 mg once daily as monotherapy & 10-15 mg once daily as adjunct to lithium or valproate. Recommended target dose: 15 mg daily as monotherapy or adjunctive treatment. May be increased to max dose of 30 mg daily.
Ped 10-17 yr Monotherapy & adjunctive therapy: Initially 2 mg daily, then titrate to 5 mg daily after 2 days & additional 2 days to reach the target dose of 10 mg daily. Subsequently, administer increments of 5 mg daily, if needed.
Adjuvant treatment of major depressive disorder Adult Initially 2-5 mg daily as adjunctive treatment. Recommended dose: 2-15 mg daily. Gradually adjust dose up to 5 mg daily at no <1 wk interval.
Irritability associated w/ autism Ped 6-17 yr Recommended dose range: 5-15 mg daily. Initially at 2 mg daily, may be increased to 5 mg daily w/ subsequent increases to 10 or 15 mg daily if needed. Gradually adjust dose up to 5 mg daily at no <1 wk interval.
Tourette's disorder Ped 6-18 yr Recommended dose range: 5-20 mg daily.
Patient weighing ≥50 kg Initially 2 mg daily for 2 days, & then increase to 5 mg daily for 5 days, w/ 10 mg daily target dose on day 8. May be increased up to 20 mg daily in patients who do not achieve optimal control of tics. Gradually adjust dose in increments of 5 mg daily at no <1 wk interval.
Patient weighing <50 kg Initially 2 mg daily w/ 5 mg daily target dose after 2 days. May further increase to 10 mg daily in patients who do not achieve optimal control of tics. Gradually adjust dose at no <1 wk interval.
Severe hepatic impairment Max: 30 mg daily.
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